Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues
نویسندگان
چکیده
منابع مشابه
Salen Mn complexes mitigate radiation injury in normal tissues.
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injury, we are investigating whether these compounds can mitigate injury to normal tissues caused by ionizing radiation. This review describes ...
متن کاملFast ( Salen ) Mn Ligand Screening
Hybrid quantum mechanics/molecular mechanics (QM/MM) methods were employed to study electronic effects of 5,5'-substituents on the enantioselectivity of (salen)Mn catalysts. Correlations obtained from the QM/MM calculations elucidated electronic framework effects on enantioselectivity for (salen)Mn heterogenized in a metal-organic framework (MOF). The correlations also enabled fast ligand scree...
متن کامل4-(Nitrophenylsulfonyl)piperazines mitigate radiation damage to multiple tissues
Our ability to use ionizing radiation as an energy source, as a therapeutic agent, and, unfortunately, as a weapon, has evolved tremendously over the past 120 years, yet our tool box to handle the consequences of accidental and unwanted radiation exposure remains very limited. We have identified a novel group of small molecule compounds with a 4-nitrophenylsulfonamide (NPS) backbone in common t...
متن کاملPrincipal component analysis of Mn(salen) catalysts.
The theoretical study of Mn(salen) catalysts has been traditionally performed under the assumption that Mn(acacen') (acacen' = 3,3'-(ethane-1,2-diylbis(azanylylidene))bis(prop-1-en-olate)) is an appropriate surrogate for the larger Mn(salen) complexes. In this work, the geometry and the electronic structure of several Mn(salen) and Mn(acacen') model complexes were studied using Density Function...
متن کاملSalen Mn Complexes are Superoxide Dismutase/Catalase Mimetics that Protect the Mitochondria
Salen Mn complexes, including EUK-134, EUK-189 and a cyclized analog EUK-207, are synthetic superoxide dismutase (SOD) and catalase mimetics that are beneficial in many models of oxidative stress. Though not designed to target the mitochondria, salen Mn complexes show "mito-protective" activity, that is, an ability to attenuate mitochondrial injury, in various experimental systems. Treatment wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Anti-Cancer Agents in Medicinal Chemistry
سال: 2011
ISSN: 1871-5206
DOI: 10.2174/187152011795677490